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2 "Young-Kyun Lee"
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Original Article
Clinical Study
Effects of Systemic Glucocorticoid Use on Fracture Risk: A Population-Based Study
Ji Weon Koh, Junkang Kim, Hyemin Cho, Yong-Chan Ha, Tae-Young Kim, Young-Kyun Lee, Ha Young Kim, Sunmee Jang
Endocrinol Metab. 2020;35(3):562-570.   Published online September 22, 2020
DOI: https://doi.org/10.3803/EnM.2020.659
  • 4,892 View
  • 178 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Long-term glucocorticoid use increases fracture risk by reducing bone mass. This study evaluated the relationship between hip and vertebral fractures and the total amount of systematic glucocorticoid use.
Methods
We randomly selected 1,896,159 people aged 20 to 100 years who participated in the National Health Checkup program in 2006. The amount of glucocorticoids prescribed was calculated based on the defined daily dose (DDD). The total DDD was obtained by adding oral and parenteral glucocorticoids for 6 months from the index date. Subjects were categorized into four groups according to total glucocorticoid DDDs: non-users (DDDs=0), low users (0< DDDs ≤45), intermediate users (45< DDDs ≤90), and high users (90< DDDs). We followed them for 2 years. A multivariate Cox proportional hazard model was used to evaluate the effects of the total amount of glucocorticoid use on hip and vertebral fractures.
Results
Higher glucocorticoid use was associated with a higher risk of vertebral fracture. Relative to non-users, the vertebral fracture risk was 1.39 times higher in the low-user group, 1.94 times higher in the intermediate-user group, and 2.43 times higher in the highuser group. The risk of hip fracture was 1.72 times higher in intermediate users and 3.28 times higher in high users than in non-users.
Conclusion
As the amount of glucocorticoid use for 6 months increased, the risk of hip and vertebral fractures became higher. In order to prevent fractures, it is necessary for doctors to evaluate the total amount of glucocorticoid prescribed to the patient and to provide appropriate treatment.

Citations

Citations to this article as recorded by  
  • Average daily glucocorticoid dose, number of prescription days, and cumulative dose in the initial 90 days of glucocorticoid therapy are associated with subsequent hip and clinical vertebral fracture risk: a retrospective cohort study using a nationwide h
    Masayuki Iki, Kenji Fujimori, Shinichi Nakatoh, Junko Tamaki, Shigeyuki Ishii, Nobukazu Okimoto, Hironori Imano, Sumito Ogawa
    Osteoporosis International.2024; 35(5): 805.     CrossRef
  • Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study
    Sung Hye Kong, Ae Jeong Jo, Chan Mi Park, Kyun Ik Park, Ji Eun Yun, Jung Hee Kim
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Bad to the bones: prescribing of drugs for the prevention and treatment of osteoporosis in patients on chronic glucocorticoids
    Sarah J. Billups, Vinh K Thai, Jacob Denkins, Ian C. Dettman, Micol S. Rothman
    Archives of Osteoporosis.2023;[Epub]     CrossRef
  • High Risk of Fractures Within 7 Years of Diagnosis in Asian Patients With Inflammatory Bowel Diseases
    Hyung Jin Ahn, Ye-Jee Kim, Ho-Su Lee, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Beom-Jun Kim, Sang Hyoung Park
    Clinical Gastroenterology and Hepatology.2022; 20(5): e1022.     CrossRef
  • Challenges in the diagnosis and management of glucocorticoid‐induced osteoporosis in younger and older adults
    Madhuni Herath, Bente Langdahl, Peter R. Ebeling, Frances Milat
    Clinical Endocrinology.2022; 96(4): 460.     CrossRef
  • Comparative effectiveness of bisphosphonate treatments for the prevention of re-fracture in glucocorticoid-induced osteoporosis: protocol for a systematic review and meta-analysis
    Hongmin Chu, Bo-Hyoung Jang, GaYoon Kim, Seowoo Bae, Hyeju Lee, Seonghee Nam, Jeonghoon Ahn
    BMJ Open.2022; 12(9): e062537.     CrossRef
  • Why Do We Need Proactive Management for Fracture Prevention in Long-Term Glucocorticoid Users?
    Han Seok Choi
    Endocrinology and Metabolism.2020; 35(3): 549.     CrossRef
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Review Article
Bone Metabolism
Epidemiology of Osteoporosis and Osteoporotic Fractures in South Korea
Young-Kyun Lee, Byung-Ho Yoon, Kyung-Hoi Koo
Endocrinol Metab. 2013;28(2):90-93.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.90
  • 4,891 View
  • 61 Download
  • 40 Web of Science
  • 44 Crossref
AbstractAbstract PDFPubReader   

Several epidemiologic studies suggested that osteoporosis and osteoporotic fractures are not uncommon in South Korea. However, these previous cohort studies had limitations that may have influenced their results and the generalizability of the study conclusions, including small sample sizes, inclusion of only women, enrollment of participants from specific areas, and nonrandom selection of participants. Recently, epidemiologic studies using a nationwide claim register have been performed to overcome these limitations through collaboration between the Korean Society of Bone and Mineral Research and Health Insurance Review Assessments. Our review of the Korean Nationwide-database Osteoporosis Study could be helpful to obtain accurate incidence and prevalence estimations of osteoporosis and osteoporosis-related fractures in Korea.

Citations

Citations to this article as recorded by  
  • The 2024 Guidelines for Osteoporosis - Korean Society of Menopause
    Dong Ock Lee, Yeon Hee Hong, Moon Kyoung Cho, Young Sik Choi, Sungwook Chun, Youn-Jee Chung, Seung Hwa Hong, Kyu Ri Hwang, Jinju Kim, Hoon Kim, Dong-Yun Lee, Sa Ra Lee, Hyun-Tae Park, Seok Kyo Seo, Jung-Ho Shin, Jae Yen Song, Kyong Wook Yi, Haerin Paik, J
    Journal of Menopausal Medicine.2024;[Epub]     CrossRef
  • Tuberculosis and osteoporotic fracture risk: development of individualized fracture risk estimation prediction model using a nationwide cohort study
    Hayoung Choi, Jungeun Shin, Jin-Hyung Jung, Kyungdo Han, Wonsuk Choi, Han Rim Lee, Jung Eun Yoo, Yohwan Yeo, Hyun Lee, Dong Wook Shin
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review
    Manju Chandran, Katherine Brind’Amour, Saeko Fujiwara, Yong-Chan Ha, Hai Tang, Jawl-Shan Hwang, James Tinker, John A. Eisman
    Osteoporosis International.2023; 34(6): 1037.     CrossRef
  • Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial
    Chaiho Jeong, Jeonghoon Ha, Jun-Il Yoo, Young-Kyun Lee, Jung Hee Kim, Yong-Chan Ha, Yong-Ki Min, Dong-Won Byun, Ki-Hyun Baek, Ho Yeon Chung
    Journal of Bone Metabolism.2023; 30(2): 189.     CrossRef
  • Risk of Fractures in Thyroid Cancer Patients With Postoperative Hypoparathyroidism: A Nationwide Cohort Study in Korea
    Seong Hee Ahn, You Jin Lee, Seongbin Hong, Jung Wee Park, Ye Jhin Jeon, Bit‐Na Yoo, Yong‐Chan Ha, Jean Kyung Bak, Ha Young Kim, Young‐Kyun Lee
    Journal of Bone and Mineral Research.2023; 38(9): 1268.     CrossRef
  • Impact of changes in physical activity and incident fracture after acute ischemic stroke
    Dae young Cheon, Kyung-Do Han, Jeen Hwa Lee, Kyung-Ho Yu, Bo Young Choi, Minwoo Lee
    Scientific Reports.2023;[Epub]     CrossRef
  • Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea
    Seulkee Heo, Honghyok Kim, Sera Kim, Seung-Ah Choe, Garam Byun, Jong-Tae Lee, Michelle L. Bell
    International Journal of Environmental Research and Public Health.2022; 19(4): 2404.     CrossRef
  • Significance of Measuring Lumbar Spine 3-Dimensional Computed Tomography Hounsfield Units to Predict Screw Loosening
    Kyeong Hwan Kim, Tae-Hwan Kim, Seok Woo Kim, Ji Hee Kim, Heui Seung Lee, In Bok Chang, Joon Ho Song, Yong-Kil Hong, Jae Keun Oh
    World Neurosurgery.2022; 165: e555.     CrossRef
  • Risk of osteoporotic fracture in older patients under antihypertensive treatment
    Oh Kyung Kwon, Sun-Hwa Kim, Si-Hyuck Kang, Young-Kyun Lee, Chang-Hwan Yoon, Hae-Young Lee, Tae-Jin Youn, In-Ho Chae, Cheol-Ho Kim
    European Journal of Preventive Cardiology.2021; 28(11): e12.     CrossRef
  • Risk factors for subsequent vertebral fractures following a previous hip fracture
    Sang-Min Park, Sung Jun Go, Heesoo Han, Jung Wee Park, Young-Kyun Lee, Ho-Joong Kim, Jin S. Yeom, Kyung-Hoi Koo
    Journal of Bone and Mineral Metabolism.2021; 39(2): 193.     CrossRef
  • Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017
    Ho-Seok Oh, Sung-Kyu Kim, Hyoung-Yeon Seo
    Healthcare.2021; 9(3): 324.     CrossRef
  • Association between Irritable Bowel Syndrome and Risk of Osteoporosis in Korean Premenopausal Women
    Sang-Yeoup Lee, Hye-Rim Hwang, Yu-Hyeon Yi, Jin-Mi Kim, Yun-Jin Kim, Jeong-Gyu Lee, Young-Hye Cho, Young-Jin Tak, Seung Hun Lee, Eun Ju Park, Youngin Lee
    Medical Principles and Practice.2021; 30(6): 527.     CrossRef
  • Association Between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Older Persons With Alzheimer's Disease
    Dae Yeon Won, Seong Jun Byun, Jin Sook Jeong, Ju-Young Shin
    Journal of the American Medical Directors Association.2020; 21(8): 1128.     CrossRef
  • High Circulating Sphingosine 1-Phosphate is a Risk Factor for Osteoporotic Fracture Independent of Fracture Risk Assessment Tool
    Seung Hun Lee, Jee Yang Lee, Kyeong-Hye Lim, Young-Sun Lee, Seong-Hee Kim, Sooyoung Choi, Seong-Hwan Cho, Jung-Min Koh
    Calcified Tissue International.2020; 107(4): 362.     CrossRef
  • Osteoporosis and Osteoporotic Fracture Fact Sheet in Korea
    Seong Hee Ahn, Sang-Min Park, So Young Park, Jun-Il Yoo, Hyoung-Seok Jung, Jae-Hwi Nho, Se Hwa Kim, Young-Kyun Lee, Yong-Chan Ha, Sunmee Jang, Tae-Young Kim, Ha Young Kim
    Journal of Bone Metabolism.2020; 27(4): 281.     CrossRef
  • Assessing the effects of National Health Insurance reimbursement policy revisions for anti-osteoporotic drugs in Korean women aged 50 or older
    Ja Seo Koo, Seong Hwan Moon, Hankil Lee, Sohee Park, Yun Mi Yu, Hye-Young Kang, Robert Daniel Blank
    PLOS ONE.2020; 15(12): e0244759.     CrossRef
  • The Epidemiology of Fracture in Patients with Acute Ischemic Stroke in Korea
    Kyung Bok Lee, Jung-Gon Lee, Beom Joon Kim, Jun Yup Kim, Keon-Joo Lee, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Keun-Sik Hong, Tai Hwan Park, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Jae-Kwan Cha, Dae-Hyun Kim, Jo
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Osteoporosis detection in panoramic radiographs using a deep convolutional neural network-based computer-assisted diagnosis system: a preliminary study
    Jae-Seo Lee, Shyam Adhikari, Liu Liu, Ho-Gul Jeong, Hyongsuk Kim, Suk-Ja Yoon
    Dentomaxillofacial Radiology.2019; 48(1): 20170344.     CrossRef
  • Medical Big Data Is Not Yet Available: Why We Need Realism Rather than Exaggeration
    Hun-Sung Kim, Dai-Jin Kim, Kun-Ho Yoon
    Endocrinology and Metabolism.2019; 34(4): 349.     CrossRef
  • Adherence to a Mediterranean Diet and Bone Mineral Density in Spanish Premenopausal Women
    Jesús Pérez-Rey, Raúl Roncero-Martín, Sergio Rico-Martín, Purificación Rey-Sánchez, Juan Pedrera-Zamorano, María Pedrera-Canal, Fidel López-Espuela, Jesús Lavado García
    Nutrients.2019; 11(3): 555.     CrossRef
  • Effect of Training and Testing Condition of Convolutional Neural Network on evaluating Osteoporosis
    Jae-Yun Kim, Jae-Seo Lee, Byung-Cheol Kang, Hyongsuk Kim, Shyam Adhikari, Liu Liu, Suk-Ja Yoon
    The Korean Journal of Oral and Maxillofacial Pathology.2019; 43(3): 73.     CrossRef
  • Comparison of intraoperative radiation exposure with and without use of distal targeting device: a randomized control study
    Jun-Il Yoo, Hojin Jeong, Jaeboem Na, Sang-Youn Song, Jung-Taek Kim, Yong-Han Cha, Chan Ho Park
    Archives of Orthopaedic and Trauma Surgery.2019; 139(11): 1579.     CrossRef
  • Anemia and Risk of Fractures in Older Korean Adults: A Nationwide Population-Based Study
    Eun Ae Lee, Dong Wook Shin, Jun Hyun Yoo, Hyeon Young Ko, Su Min Jeong
    Journal of Bone and Mineral Research.2019; 34(6): 1049.     CrossRef
  • Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption
    Beom-Jun Kim, Jin Young Lee, So Jeong Park, Seung Hum Lee, Su Jung Kim, Hyun Ju Yoo, Sarah I. Rivera De Pena, Meghan McGee-Lawrence, Carlos M. Isales, Jung-Min Koh, Mark W. Hamrick
    Aging.2019; 11(21): 9388.     CrossRef
  • Effect of improved medication adherence on health care costs in osteoporosis patients
    Hyemin Cho, Ji-Hye Byun, Inmyung Song, Ha Y. Kim, Yong-Chan Ha, Tae-Young Kim, Young-Kyun Lee, Sunmee Jang
    Medicine.2018; 97(30): e11470.     CrossRef
  • Osteoporosis and fracture after gastrectomy for stomach cancer
    Gi Hyeon Seo, Hae Yeon Kang, Eun Kyung Choe
    Medicine.2018; 97(17): e0532.     CrossRef
  • Inflammation inhibitory effect of water extract from pumpkin’s tendril
    Ha-Na Jeong, Ju-Hee Choi, Ha-Nul Lee, So-Hyeon Lee, Soon-Chang Cho, Jong-Hwan Park, Young-Min Kim
    Korean Journal of Food Preservation.2017; 24(8): 1122.     CrossRef
  • Strong familial association of bone mineral density between parents and offspring: KNHANES 2008–2011
    H. S. Choi, J. H. Park, S. H. Kim, S. Shin, M. J. Park
    Osteoporosis International.2017; 28(3): 955.     CrossRef
  • Vertebral bone attenuation on low-dose chest CT: quantitative volumetric analysis for bone fragility assessment
    Y. W. Kim, J. H. Kim, S. H. Yoon, J. H. Lee, C.-H. Lee, C. S. Shin, Y. S. Park
    Osteoporosis International.2017; 28(1): 329.     CrossRef
  • Factors Affecting Bone Mineral Density Measurement after Fracture in South Korea
    Jin-Woo Kim, Yong-Chan Ha, Young-Kyun Lee
    Journal of Bone Metabolism.2017; 24(4): 217.     CrossRef
  • Femoral geometry, bone mineral density, and the risk of hip fracture in premenopausal women: a case control study
    Dong-Hwa Lee, Kyong Yeun Jung, A Ram Hong, Jung Hee Kim, Kyoung Min Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim
    BMC Musculoskeletal Disorders.2016;[Epub]     CrossRef
  • The Association of Higher Plasma Macrophage Migration Inhibitory Factor Levels with Lower Bone Mineral Density and Higher Bone Turnover Rate in Postmenopausal Women
    Hyeonmok Kim, Seong Hee Ahn, Chaeho Shin, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh
    Endocrinology and Metabolism.2016; 31(3): 454.     CrossRef
  • Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
    Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
    PLOS ONE.2016; 11(3): e0150531.     CrossRef
  • The effects of body mass index on the hereditary influences that determine peak bone mass in mother–daughter pairs (KNHANES V)
    K. M. Kim, Y. J. Kim, S. H. Choi, S. Lim, J. H. Moon, J. H. Kim, S. W. Kim, H. C. Jang, C. S. Shin
    Osteoporosis International.2016; 27(6): 2057.     CrossRef
  • Low Bone Mineral Density Is Associated with Tooth Loss in Postmenopausal Women: A Nationwide Representative Study in Korea
    Soyeon Ji, Young Jin Tak, Dong Hun Han, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Dong Wook Jeong, Min Ji Kim
    Journal of Women's Health.2016; 25(11): 1159.     CrossRef
  • The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study
    S. J. Bae, S. H. Lee, S. H. Ahn, H.-M. Kim, B.-J. Kim, J.-M. Koh
    Osteoporosis International.2016; 27(8): 2533.     CrossRef
  • Is central skeleton bone quality a predictor of the severity of proximal humeral fractures?
    Seung Yeol Lee, Soon-Sun Kwon, Tae Hoon Kim, Sang-Jin Shin
    Injury.2016; 47(12): 2777.     CrossRef
  • Association of the TREML2 and HTR1E Genetic Polymorphisms with Osteoporosis
    Dongju Jung, Hyun-Seok Jin
    Biomedical Science Letters.2015; 21(4): 181.     CrossRef
  • A Large National Cohort Study of the Association between Bisphosphonates and Osteonecrosis of the Jaw in Patients with Osteoporosis
    J.-W. Kwon, E.-J. Park, S.-Y. Jung, H.S. Sohn, H. Ryu, H.S. Suh
    Journal of Dental Research.2015; 94(9_suppl): 212S.     CrossRef
  • Reliability and validity of lower extremity computed tomography as a screening tool for osteoporosis
    S. Y. Lee, S.-S. Kwon, H. S. Kim, J. H. Yoo, J. Kim, J. Y. Kim, B. C. Min, S. J. Moon, K. H. Sung
    Osteoporosis International.2015; 26(4): 1387.     CrossRef
  • Osteoporosis in Healthy South Indian Males and the Influence of Life Style Factors and Vitamin D Status on Bone Mineral Density
    Sahana Shetty, Nitin Kapoor, Dukhabandhu Naik, Hesarghatta Shyamasunder Asha, Suresh Prabu, Nihal Thomas, Mandalam Subramaniam Seshadri, Thomas Vizhalil Paul
    Journal of Osteoporosis.2014; 2014: 1.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Association of osteoporosis susceptibility genes with bone mineral density and bone metabolism related markers in Koreans: The Chungju Metabolic Disease Cohort (CMC) study
    Se Eun Park, Ki Won Oh, Won Young Lee, Ki Hyun Baek, Kun Ho Yoon, Ho Young Son, Won Chul Lee, Moo Il Kang
    Endocrine Journal.2014; 61(11): 1069.     CrossRef
  • Management of Osteoporosis: Who to Treat, What to Use, and for How Long?
    Sang Wan Kim
    Korean Journal of Medicine.2013; 85(4): 364.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism